History of AROMASIN (EXEMESTANE):
Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of postmenopausal women with hormonally responsive (also known as hormone-receptor-positive, estrogen-responsive) breast cancer. It binds to the active site of the enzyme in an irreversible manner, leading to persistent inhibition.
Chemical Formula of AROMASIN (EXEMESTANE):
Indication of AROMASIN (EXEMESTANE):
To treat advanced breast cancer in postmenopausal women whose illness has progressed after tamoxifen therapy. This medicine is used to treat specific forms of breast cancer in women following menopause (such as hormone-receptor-positive breast cancer). Exemestane is also used to assist prevent cancer recurrence. A natural hormone called oestrogen stimulates the growth of some breast tumors.
Mechanism of action of AROMASIN (EXEMESTANE):
The development of breast cancer cells may be estrogen-dependent. Aromatase is the primary enzyme responsible for converting androgens to estrogens in both pre-and postmenopausal women. While the ovary is the primary source of oestrogen in premenopausal women, the aromatase enzyme in postmenopausal women converts adrenal and ovarian androgens to estrogens. Exemestane dramatically decreases circulating oestrogen concentrations in postmenopausal women but has no effect on corticosteroid or aldosterone production in the adrenal gland. This decrease in serum and tumor oestrogen concentrations slows tumor development and disease progression.
How to use AROMASIN (EXEMESTANE):
AROMASIN is a tablet that should be taken whole with water. The typical treatment is to take 1-2 pills three times each day. After a few months, your doctor may reduce the dosage to one pill two to three times per day.
Side effects of AROMASIN (EXEMESTANE):
Common side effects may include:
- hot flashes;
- headache, feeling tired;
- joint pain;
- increased appetite;
- sleep problems
Keep this drug away from heat, moisture, and light at 68°F to 77°F (20°C to 25°C). Keep any medications out of children’s reach. After the expiration date, throw away any unused medicine. Do not dump or spill unused drugs down the sink or drain.