History of LETROZOLE:
Letrozole, also known as CGS 20267, is a nonsteroidal type II aromatase inhibitor that was originally identified in the literature in 1990. It is a third-generation aromatase inhibitor, like exemestane and anastrozole, which means it does not affect cortisol, aldosterone, or thyroxine levels.
Chemical Formula of LETROZOLE:
Indication of LETROZOLE:
Letrozole is approved for the treatment of postmenopausal women with hormone receptor (HR) positive early breast cancer, postmenopausal women with early breast cancer who have already had tamoxifen treatment, and postmenopausal women with HR+ or unknown advanced breast cancer. Letrozole, in combination with ribociclib, is indicated for the treatment of premenopausal, perimenopausal, and postmenopausal women with HR+ and HER2 negative advanced or metastatic breast cancer.
Mechanism of action of LETROZOLE:
Letrozole is a non-steroidal aromatase inhibitor of type II. It obstructs the active site of CYP19A1 and hence the electron transfer chain. This competitive inhibition inhibits androgens from being converted to oestrogen. This action results in a decrease in uterine weight and an increase in luteinizing hormone. In postmenopausal women, the action of aromatase is responsible for the majority of oestrogen production. With the reduced availability of oestrogen, estrogen-dependent cancers regress.8 Third generation aromatase inhibitors do not significantly alter cortisol, aldosterone, and thyroxine levels
How to use LETROZOLE:
Letrozole suggested dose is one 2.5 mg tablet taken once a day, without regard for food. Take the medication exactly as directed by your primary care physician. While ingesting the tablet, drink a glass of water.
side effects of letrozole include:
- headaches, nausea, and vomiting.
- change of appetite.
- carpal tunnel syndrome.
- hair and skin changes.
- vaginal bleeding.
Keep this drug away from heat, moisture, and light at 68°F to 77°F (20°C to 25°C). Keep any medications out of children’s reach. After the expiration date, throw away any unused medicine. Do not dump or spill unused drugs down the sink or drain.